Willeke van Roon-Mom

Organizing committee

Assistant Professor
Leiden University Medical Center, (LUMC) Department of Human Genetics

I have worked for more than 15 years in polyglutamine disorder research and in particular Huntington Disease research. In New Zealand, the first part of my career was focused on protein protein interactions inHuntington’s disease using post mortem human brain tissue and in vitro models. More recently I moved back to The Netherlands where I work in the department of Human Genetics of the LUMC where my work is mainly focused on gene expression changes in HD models and patient material and the development of novel therapeutic strategies for HD and other polyglutamine disorders.

Expertise
• Molecular biology
• Experimental therapeutics
• Post mortem human brain tissue
• Novel genome technologies

Techniques
• Antisense oligonucleotides
• Next generation sequencing
• ChIPseq
• Immunohistochemistry

Selection of the most relevant/recent publications
• A.E. Ivliev, P.A.C. ’t Hoen, W.M.C. van Roon Mom, D.J. Peters, M.G. Sergeeva. Exploring the transcriptome of ciliated cells using in silico dissection of human tissues. PlosOne 2012;7(4):e35618
• E.M. Dumas, M. Versluis, S.J.A. van den Bogaard, M.J.P. van Osch, E.P. ‘t Hart, W.M.C. van Roon Mom, M.A. van Buchem, A.G. Webb, J. van der Grond, R.A.C. Roos, and the TRACK HD investigators. Elevated brain iron is predictive of disease state in Huntington’s Disease. Epub Neuroimage March 28, 2012
• A. Mastrokolias, J.T. den Dunnen, G.J.B. van Ommen, P.A.C. ’t Hoen, W.M.C. van Roon Mom. Globin reduction in RNA from human peripheral blood increases sensitivity of next generation sequencing based expression profiling. BMC Genomics 13(1)(2012):28 37.
• M.M. Evers, J.C.T. van Deutekom, A.M. Aartsma Rus, P. Paganetti, J.T. den Dunnen, G.J.B. van Ommen, and W.M.C. van Roon Mom. Specific reduction of prolonged CAG repeat containing transcripts using antisense oligonucleotides. PLoS One. 2011;6(9):e24308. Epub 2011 Sep 1
• I. Zalachorasa, M.M. Evers, W.M.C. van Roon Mom, A.M. AartsmaRus, O.C. Meijer. Antisense mediated RNA targeting: versatile and 1 expedient genetic manipulation in the brain. Frontiers in Molecular Neuroscience. (2011) Vol 4 article 10
• H.H. van Haagen, P.A.C. ‘t Hoen, A. de Morrée, W.M.C. van Roon Mom, D.J. Peters, M. Roos, B. Mons, G.J.B. van Ommen, M.J. Schuemie. In silico discovery and experimental validation of new protein protein interactions. Proteomics. 2011 Mar;11(5):843 53.
• N.A. Aziz, C.K. Jurgens, G.B. Landwehrmeyer, EHDN Registry Study Group, W.M.C. van RoonMom, G.J.B. van Ommen, T. Stijnen, R.A.C. Roos. Normal and Mutant HTT interact to affect clinical severity and progression in Huntington disease. Neurology (2009) 73(16):1280 5
• B.A. Pepers, M.H. Schut, R.H.A.M. Vossen, G.J.B. van Ommen, J.T. den Dunnen, W.M.C. van Roon Mom. Cost effective HRMA pre sequence typing of clone libraries; application to phage display selection. BMC Biotechnology (2009) 9: 50 56
• W.M.C. van Roon Mom, B.A. Pepers, P.A.C. ‘t Hoen, C.A.C.M. Verwijmeren, J.T. den Dunnen, J.C. Dorsman, G.J.B. van Ommen. Mutant huntingtin activates Nrf2 responsive genes and impairs dopamine synthesis in a PC12 model of Huntington’s disease. BMC Molecular Biology (2008), 9(1): 84 97
• M.A. Curtis, M. Kam, U. Nannmark, M.F. Anderson, M. Zetterstrom Axell, C. Wikkelso, S. Holtås, W.M.C. van Roon Mom, T. Björk Eriksson, C. Nordborg, J. Frisén, M. Dragunow, R.L.M. Faull, P.S. Eriksson. Human Neuroblasts Migrate to the Olfactory Bulb via a Lateral Ventricular Extension. Science (2007) Vol 315, 2 March:1243 1249