Programme Friday November 5, 2021

Joint meeting DHDRN (Dutch Huntington Disease Research Network) and HKNN (Huntington KennisNet Nederland)
10.00-10.10 | Welcome
Mayke Oosterloo; Neurologist, Maastricht UMC+
10.10-10.15 | Introduction
Chair: Eric Reits, Professor, Amsterdam University Medical Center, (AUMC) Department Medical Biology
10.15-10.45 | Plenary Session
MRI as a source for biomarker research >
David Linden, Professor Translational Neuroscience and Scientific Director of the School for Mental Health and Neuroscience (MHeNs) Maastricht University
Huntington Partner in Balance: online self-management for partners/caregivers of persons with Huntington Disease (HD) >
Annelien Duits, Clinical neuropsychologist at the Department of Psychiatry and Psychology of Maastricht University Medical Center, (MUMC+) 
10.45-12.00 | Introduction Parallel sessions 1 and 2
Chair: Mayke Oosterloo, Neurologist, Maastricht University Medical Center, (MUMC+) 

Session 1: Basic Scientific, 3 selected presentations
Chair: Willeke van RoonProfessor, Leiden University Medical Center, (LUMC) Department of Human Genetics
01. Changes in proteasome ub-receptors Rpn10 and Rpn13 affect Htt degradationKarlijne Geijtenbeek
02. Effect of small molecule inhibitors on the aggregation mechanism of Huntington Exon1Greeshama Jain
03. Identification of wild-type and mutant huntingtin interaction partners by cross-linking immunoprecipitation and LFQ-based mass spectrometryKaren Sap

Session 2: Clinical Scientific (Dutch), 3 selected presentations
Chair: Susanne de Bot, neurologist, specialized in Movement disorders, Leiden University Medical Center, (LUMC) Department Neurology
04. Burn-outKasper van der Zwaan
05. Study update and design direction for the development of a European e-health platform for individuals with HD and their partners (HD-eHelp study)Pearl van Lonkhuizen
06. Research participation in HD: perceptions and experiences of the Dutch communityFilipa Julio
12.00-12.30 | Lunch break
12.30-12.35 | Introduction
Chair: Mayke Oosterloo; Neurologist, Maastricht University Medical Center, (MUMC+) 
12.35-13.20 | Keynote lecture
How the Huntington Gene Affects Brain Development (Pre-recorded) >
Peggy C. Nopoulos, Professor of Psychiatry, Department of Neurology, University of Iowa; Carver College of Medicine
13.20-13.40 | Break
13.40-14.15 | Lecture
Chair: Harm Kampinga, Professor, University Medical Center Groningen, (UMCG) Department of Human Genetics
15 years visualizing the role of the ubiquitin-proteasome in HD >
Eric Reits, Professor, Amsterdam University Medical Center, (AUMC) Department Medical Biology
14.15-15.00 | Session 3: Clinical Scientific (Dutch) 3 selected presentations
Chair: David Linden, Professor, neuropsychiatry, Maastricht University Medical Center, (MUMC+) 
07. Efficacy and safety for tiapride for chorea treatment in HD: a systematic reviewStephanie Feleus
08. Treatment of neuropsychiatric symptoms in Huntington’s Disease: a retrospective cohort studyRuben Andriessen
09. Pridopidine maintenance of TFC is associated with stabilization of plasma NfL levelsMichal Geva
15.00-15.30 | Awards
Chair: Rob Haselberg, Vereniging van Huntington (VvH)
• Huntington Stimulation Grant Award (Presentation granted project)
• Best abstract Award
15.30 | Closing
Mayke Oosterloo, Neurologist, Maastricht University Medical Center, (MUMC+)